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Api-Life VAR is the best miteacide you can use against Varroa Mites. It is 95% effective while leaving the least residue of any product available to beekeepers (legal or illegal). Treat each colony by breaking 1 wafer into 4 pieces and placing around the brood nest. Leave 7 to 10 days and replace with another wafer and after 7 to 10 days replace for a 3rd time. This will complete the treatment. Treatment most effective at average daytime temperatures of 65°.